Storage Conditions: Keep in a cool, well-ventilated area, preferably at low temperature
Physical Properties
Melting Point: 165-167°C
Solubility: Slightly soluble in cold water, soluble in methanol and hot water, practically insoluble in ethanol (96%)
Pharmacological Actions
Propafenone Hydrochloride is a Class Ic sodium channel blocker, which is a broad-spectrum antiarrhythmic agent. Its main mechanisms of action include:
Reducing the spontaneous excitability of myocardial cells, prolonging conduction, and action potential duration and effective refractory period.
Elevating the threshold potential of myocardial cells, reducing myocardial irritability.
Possessing membrane-stabilizing effects and competitive β-blocking effects.
Exhibiting mild calcium antagonist effects (100 times weaker than verapamil).
Having a mild inhibitory effect on myocardial contractility, increasing end-diastolic pressure, reducing stroke volume, and causing mild hypotension and bradycardia.
Indications
Propafenone Hydrochloride is primarily used for the prevention and treatment of the following arrhythmias:
Paroxysmal ventricular tachycardia
Paroxysmal supraventricular tachycardia
Wolff-Parkinson-White syndrome with supraventricular tachycardia
