Minocycline Hydrochloride is a semisynthetic tetracycline antibiotic known for its high potency, rapid onset, and prolonged duration of action.
Basic Information
English Name: Minocycline Hydrochloride
CAS Number: 13614-98-7
Molecular Formula: C23H28N3O7
Molecular Weight: 493.94
Pharmacological Action
Antibacterial Spectrum: Minocycline Hydrochloride exhibits a broad spectrum of antibacterial activity, effective against tetracycline-sensitive and tetracycline-resistant strains of Staphylococcus aureus. It also demonstrates stronger activity against Streptococcus viridans, Actinomyces israelii, Streptococcus pneumoniae, Neisseria gonorrhoeae, and other bacterial-like microorganisms. Its activity against Escherichia coli, Proteus vulgaris, Salmonella, Shigella, Klebsiella pneumoniae, and Pseudomonas aeruginosa is comparable to other tetracycline antibiotics.
Mechanism of Action: It binds to the 30S subunit of bacterial ribosomes, inhibiting peptide chain elongation and thereby blocking protein synthesis, resulting in bacteriostatic effects.
Clinical Applications
Minocycline Hydrochloride is widely used in the treatment of acne, non-gonococcal urethritis, and other infectious diseases.
It is also indicated for respiratory, urinary, skin, and soft tissue infections caused by drug-resistant bacteria, as well as meningitis and its carriers, chronic osteomyelitis, cholecystitis, gonorrhea, and other conditions.
