Molecular Formula: C12H19ClN2O4 (Note: Molecular weights may vary slightly depending on the calculation method or state of the compound)
Physical Properties
Melting Point: 192-193°C
Boiling Point: 529.9°C at 760 mmHg
Flash Point: 274.3°C
Storage Conditions: Recommended to store at -20°C in a freezer to maintain stability.
Pharmacological Actions
Midodrine Hydrochloride is a prodrug that is metabolized in the body to its active form, desglymidodrine, via enzymatic hydrolysis. Desglymidodrine selectively stimulates peripheral α-adrenergic receptors, primarily in small arterial and venous smooth muscle, resulting in vasoconstriction and thus increased blood pressure. It does not have an effect on myocardial β-adrenergic receptors.
Indications
Midodrine Hydrochloride is primarily used to manage orthostatic hypotension, including hypotension caused by venous pooling in the lower extremities, postoperative hypotension, postpartum hypotension, hypotension associated with climate changes, and fatigue upon rising in the morning. Additionally, it can be used to treat stress urinary incontinence in women.
