Alternative Names: 4-Oxo-5-methylpyrazine-2-carboxylic acid; Olipure
CAS Number: 51037-30-0
EINECS Number: 256-928-3
Molecular Formula: C6H6N2O3
Molecular Weight: 154.12
Physical Properties
Appearance: Powder/Liquid
Density: 1.44 g/cm³
Boiling Point: 539°C at 760 mmHg
Flash Point: 279.8°C
Vapor Pressure: 1.88E-12 mmHg at 25°C
Uses
Acipimox is an anti-lipidemic drug belonging to the nicotinic acid derivatives. It inhibits the release of free fatty acids from adipose tissue, resulting in reduced entry of free fatty acids into the liver, thereby blocking the synthesis of triglycerides (TG). Furthermore, it activates lipoprotein lipase, reducing VLDL-C (very low-density lipoprotein cholesterol) and LDL-C (low-density lipoprotein cholesterol), leading to decreased TG and total TC (total cholesterol) levels, and increased HDL (high-density lipoprotein) levels.
Storage and Transportation
Acipimox should be stored in a cool, well-ventilated place and kept at low temperatures. The shelf life is generally 24 months, but if retested and found to be compliant, it can still be used after expiration. During transportation, attention should be paid to avoid adverse conditions such as high temperatures, humidity, and direct sunlight.
Safety Information
Safety precautions should be observed when handling and storing Acipimox. According to available information, safety information includes GHS symbols (e.g., GHS07), signal words (e.g., Warning), and hazard statements (e.g., H319). Appropriate personal protective equipment, such as N95 respirators, safety glasses, and gloves, should be worn during handling.
In summary, Acipimox (CAS NO.: 51037-30-0) is an important lipid-lowering drug with broad application prospects. Safety precautions and regulations should be followed during use and storage.
