Fluvastatin Sodium

General Information

Fluvastatin Sodium, marketed as Lescol by Novartis Pharmaceuticals, is a commonly used hypolipidemic drug.

• Chemical Name: 氟伐他汀钠

• English Name: Fluvastatin Sodium

• CAS Number: 93957-55-2

• Molecular Formula: C24H25FNNaO4

• Molecular Weight: 433.4478

Physical Properties

• Appearance: Fluvastatin Sodium is a white to slightly yellow crystalline powder that is highly hygroscopic.

• Physical Characteristics: Melting point 194-197°C, boiling point 681.8°C at 760 mmHg, flash point 366.1°C, vapor pressure 1.6E-19 mmHg at 25°C.

Pharmacological Action

Fluvastatin Sodium is a fully synthetic cholesterol-lowering drug belonging to the class of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Its main mechanisms of action include:

1. Inhibition of Cholesterol Synthesis: Competitively inhibits HMG-CoA reductase, reducing endogenous cholesterol synthesis.

2. Increase in LDL Receptor Number and Activity: Through negative feedback regulation, increases the number and activity of low-density lipoprotein (LDL) receptors on hepatocyte surfaces, promoting LDL uptake and catabolism.

3. Decreases Plasma Cholesterol Concentration: Significantly reduces plasma total cholesterol, LDL-cholesterol, and triglyceride levels while increasing high-density lipoprotein cholesterol levels.

Indications

Fluvastatin Sodium is indicated for the treatment of:

• Primary hypercholesterolemia not adequately controlled by diet.

• Mixed dyslipidemia (e.g., Fredrickson types IIa and IIb).

Storage Conditions

Fluvastatin Sodium should be stored in a dry, light-protected environment, preferably at -20°C.