Chinese Synonyms: Nimodipine, (+/-)-4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid methoxyethyl ester isopropyl ester, Lemodipine, Nimodipine (Nifedipine derivative), Nimotidine, etc.
English Synonyms: Nimodipine, 1,4-Dihydro-2,6-dimethyl-4-(3'-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl-1-methylethyl ester, etc.
Physical Properties
Appearance: Pale yellow crystalline powder, odorless, tasteless.
Solubility: Soluble in ethanol or acetone, insoluble in water.
Melting Point: 124-128°C
Boiling Point: 536.21°C (rough estimate)
Density: 1.3268 g/cm³ (rough estimate)
Refractive Index: 1.6500 (estimate)
Chemical Properties
Nimodipine is a new generation of 1,4-dihydropyridine calcium channel blocker (calcium antagonist). It inhibits the influx of extracellular calcium ions into vascular smooth muscle cells.
Pharmacological Effects
Easily crosses the blood-brain barrier to act on cerebral blood vessels and nerve cells.
Selectively dilates cerebral blood vessels without causing "steal phenomenon," increasing cerebral blood flow without affecting cerebral metabolism.
Antagonizes cerebral vasospasm caused by K+, 5-HT, arachidonic acid, hydrogen peroxide, TXA2, DGF2a, and subarachnoid hemorrhage.
Has antidepressant effects and improves learning and memory functions.
Also reduces erythrocyte fragility, plasma viscosity, and inhibits platelet aggregation.
Indications
Primarily used for the prevention and treatment of ischemic neurological damage caused by cerebral vasospasm after subarachnoid hemorrhage, as well as senile cerebral dysfunction, migraine, sudden deafness, etc.
