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Nifedipine
    Publish time 2024-09-19 16:42    

CAS NO.: 21829-25-4

Nifedipine

Basic Information

  • Chinese Name: 硝苯地平

  • English Name: Nifedipine

  • CAS Number: 21829-25-4

  • Molecular Formula: C17H18N2O6

  • Molecular Weight: 346.33~346.34 (may vary slightly from different sources)

  • EINECS Number: 244-598-3

Physical Properties

  • Appearance and Odor: Yellow crystalline powder or solid, odorless, tasteless

  • Density: 1.271 g/cm³

  • Melting Point: 171-175°C (may vary slightly from different sources)

  • Boiling Point: 475.3°C at 760 mmHg

  • Flash Point: 241.2°C

  • Solubility: Easily soluble in acetone or chloroform, slightly soluble in ethanol, practically insoluble in water

Chemical Properties

Nifedipine is a cardiovascular drug primarily used in the treatment of various acute and chronic coronary insufficiencies, angina pectoris, and other conditions. It works by inhibiting the membrane transport of calcium ions in cardiac and vascular smooth muscle, thus inhibiting the influx of calcium ions into cells. This leads to reduced myocardial contractility and vasodilation, ultimately lowering blood pressure and relieving angina symptoms.

Uses

  • Uses: Nifedipine has a wide range of clinical applications as a cardiovascular drug. It can be used alone or in combination with other drugs to achieve better therapeutic effects.

Storage Conditions

Nifedipine should be stored in a cool, dry, well-ventilated place, away from fire and heat sources. It should also be protected from direct sunlight and moisture to prevent deterioration or loss of potency.