Diltiazem Hydrochloride, also known as Diltiazem HCl, is a calcium channel blocker (also referred to as a slow channel blocker or calcium antagonist). Below is a detailed introduction to Diltiazem Hydrochloride:
Basic Information
English Name: Diltiazem Hydrochloride
Chinese Name: 盐酸地尔硫卓
CAS Number: 33286-22-5
Molecular Formula: C22H27ClN2O4S
Molecular Weight: 450.98
Pharmacological Action
Diltiazem Hydrochloride primarily works by inhibiting the influx of calcium ions into myocardial and vascular smooth muscle cells during depolarization. It effectively dilates epicardial and endocardial coronary arteries, alleviating angina pectoris, whether spontaneous or induced by ergotamine-induced coronary artery spasm. Additionally, by slowing heart rate and reducing blood pressure, it decreases myocardial oxygen demand, increases exercise tolerance, and relieves effort angina. Furthermore, it relaxes vascular smooth muscles, reducing peripheral vascular resistance and blood pressure, with the extent of blood pressure reduction correlating with the severity of hypertension.
Indications
Diltiazem Hydrochloride is primarily used to treat the following conditions:
