Basic Information:

• Chinese Name: 沙格列汀

• English Name: Saxagliptin

• CAS Number: 361442-04-8

• Molecular Formula: C18H25N3O2

• Molecular Weight: 315.41

• Appearance: White powder

Physical Properties:

• Density: 1.35 g/cm³

• Boiling Point: 548.7°C at 760 mmHg

• Flash Point: 285.6°C

• Refractive Index: 1.64 (estimated)

Pharmacological Action:

Saxagliptin, a selective and reversible DPP-4 (dipeptidyl peptidase-4) inhibitor, functions by inhibiting the DPP-4 enzyme. This slows down the degradation of GLP-1 (glucagon-like peptide-1) and GIP (gastric inhibitory polypeptide), thereby increasing their plasma concentrations. This enhanced level promotes glucose-dependent insulin secretion and decreases glucagon levels, ultimately regulating blood glucose levels.

Indications:

Saxagliptin is primarily used for glycemic control in patients with type 2 diabetes, particularly when diet and exercise fail to adequately manage blood sugar levels. It can be used as monotherapy or in combination with other antidiabetic agents.