Ivabradine Hydrochloride

Basic Information:

• Generic Name: Ivabradine Hydrochloride

• Chemical Name: 3-(3-{[((7S)-3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl]methylamino}propyl)-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one hydrochloride

• Molecular Formula: C27H36N2O5•HCl

• Molecular Weight: 505.1 (may vary slightly depending on sources, e.g., 505.05)

• CAS Number: 148849-67-6

Indications:

• Indications: Ivabradine Hydrochloride is indicated for the treatment of patients with chronic heart failure (NYHA class II-IV) with systolic dysfunction and a sinus rhythm with a heart rate ≥75 beats per minute (bpm), in conjunction with standard therapy (including beta-blockers) or when beta-blockers are contraindicated or not tolerated.

Adverse Reactions:

• The most common adverse reactions reported in clinical studies for Ivabradine Hydrochloride include phosphenes (visual brightness) and bradycardia, both of which are dose-dependent. Other more common adverse reactions include dizziness, headache, blurred vision, cardiac disorders (such as first-degree atrioventricular block, ventricular extrasystoles, atrial fibrillation), etc.

• Less common or rare adverse reactions include eosinophilia, hyperuricemia, syncope, diplopia, visual disturbances, palpitations, hypotension, dyspnea, nausea, vomiting, diarrhea, angioedema, rash, muscle spasms, increased serum creatinine levels, etc.

Storage Conditions:

• Ivabradine Hydrochloride should be stored in a dry, cool, well-ventilated place, protected from direct sunlight and excessive heat. Specific storage conditions may vary depending on different manufacturers and packaging specifications.