Indapamide is an oral antihypertensive medication and a thiazide-like diuretic. The following provides a detailed overview of Indapamide:
Basic Information
English Name: Indapamide
Chinese Name: 吲达帕胺
CAS Number: 26807-65-8
Alternative Names: Lifeshan, Natrilix SR, Natrilix, Indapamide SR, etc.
Molecular Formula: C16H16ClN3O3S
Molecular Weight: 365.83
Chemical Name: N-(2-methyl-2,3-dihydro-1H-indol-1-yl)-3-sulfamoyl-4-chlorobenzamide
Physical Properties
Indapamide is a white to off-white, crystalline powder that is odorless and tasteless.
It is freely soluble in acetone and glacial acetic acid, soluble in ethanol or ethyl acetate, slightly soluble in chloroform or ether, and practically insoluble in water and dilute hydrochloric acid.
Its melting point ranges from 162°C to 167°C (the temperature of the meniscus formation is taken as the complete melting temperature).
Pharmacological Action
Indapamide exhibits both diuretic and calcium antagonist effects. By inhibiting the reabsorption of Na+ in the proximal tubules of the ascending loop of Henle, it produces a diuretic effect. Additionally, it blocks the influx of Ca2+ into vascular smooth muscle cells, selectively dilating peripheral small blood vessels, leading to a hypotensive effect.
The vasodilatory effect of Indapamide is more potent than its diuretic action, and it can reduce blood pressure even at doses lower than those required for diuresis.
Indications
Indapamide is indicated for the treatment of mild to moderate essential hypertension.
It can also be used in cases of water and sodium retention due to congestive heart failure.
It is suitable for patients with hypertension accompanied by renal failure, diabetes, or hyperlipidemia. Significant blood pressure reduction is observed with monotherapy, and its efficacy is enhanced when combined with beta-blockers.
Drug Interactions
Indapamide interacts with various medications, such as amiodarone, which may lead to arrhythmias when co-administered. It also weakens the anticoagulant effect of oral anticoagulants. Therefore, patients should inform their healthcare providers of all medications they are currently taking to avoid adverse drug interactions.
In summary, Indapamide is an effective antihypertensive and diuretic medication.
