Tafluprost

Tafluprost, as an antiglaucoma prostaglandin analog, holds significant value in the field of ophthalmic treatment.

I. Basic Information

• English Name: Tafluprost

• Alternative Names: AFP-168, MK-2452

• CAS Number: 209860-87-7

• Molecular Formula: C25H34F2O5

• Molecular Weight: 452.53

II. Pharmacological Action

• Tafluprost is an antiglaucoma prostaglandin (PG) analog that reduces intraocular pressure (IOP) by increasing uveoscleral outflow.

• It is considered a selective FP prostaglandin receptor agonist, though the exact mechanism of action is not fully understood.

• Tafluprost has been shown to inhibit retinal ganglion cell (RGC) and rat RGC apoptosis, promote axonal regeneration by modulating the Zn2+-mTOR pathway, and inhibit intracellular lipid accumulation in human preorbital adipocytes.

III. Clinical Application

• Tafluprost is primarily used to treat open-angle glaucoma or ocular hypertension in patients, by lowering IOP to alleviate symptoms and prevent disease progression.