Macitentan is an orally active, non-peptide dual antagonist of endothelin receptors A and B (ETA and ETB) with the chemical formula C19H20Br2N6O4S and a molecular weight of 588.2729. Its CAS registry number is 441798-33-0.

Basic Information

• Generic Name: Macitentan

• Chemical Formula: C19H20Br2N6O4S

• Molecular Weight: 588.2729

• CAS Registry Number: 441798-33-0

Pharmacological Action

Macitentan acts as an endothelin receptor antagonist by blocking the ETA and ETB receptors, thereby reducing vasoconstriction, decreasing the pressure on the heart, and improving lung and heart function. It is particularly effective in the treatment of pulmonary arterial hypertension (PAH), a rare but severe lung vascular disease characterized by abnormally high blood pressure in the pulmonary arteries.

Clinical Use

• Indications: Macitentan is primarily used for the treatment of pulmonary arterial hypertension (PAH).

• Efficacy: In clinical trials, Macitentan has demonstrated significant efficacy and safety. It effectively reduces pulmonary vascular resistance, improves cardiac function, increases exercise tolerance, slows disease progression, and improves survival rates in patients with PAH.