The CAS number 366789-02-8 corresponds to the chemical substance Rivaroxaban. Here's a detailed translation of the information provided:

Basic Information

• Chinese Name: 利伐沙班

• English Name: Rivaroxaban

• CAS Number: 366789-02-8

• Molecular Formula: C19H18ClN3O5S

• Molecular Weight: 435.88

Physical and Chemical Properties

• Melting Point: 228-229°C

• Boiling Point: 732.6°C at 760 mmHg

• Density: 1.46g/cm³

• Flash Point: 396.9°C

• Refractive Index: 1.633

• Appearance: White crystalline powder

• Solubility: Insoluble in water, but soluble in organic solvents such as chloroform and DMSO

Uses and Pharmacological Effects

• Uses: Rivaroxaban is a highly selective oral anticoagulant used primarily for the prevention and treatment of venous thromboembolic diseases (such as deep vein thrombosis and pulmonary embolism), as well as for the prevention of stroke and systemic embolism in patients with atrial fibrillation. It is also used to prevent venous thromboembolic events after orthopedic surgeries (e.g., hip or knee replacement surgeries).

• Pharmacological Effects: Rivaroxaban exerts its anticoagulant effects by directly inhibiting factor Xa, thereby interrupting both the intrinsic and extrinsic pathways of the coagulation cascade and inhibiting the production of thrombin and thrombus formation. It does not inhibit thrombin (activated factor II) and has not been shown to affect platelets.

In summary, the CAS number 366789-02-8 corresponds to the chemical substance Rivaroxaban, an important anticoagulant drug that plays a crucial role in the prevention and treatment of venous thromboembolic diseases and stroke in atrial fibrillation patients.