Amlodipine Besylate, also known as Amlodipine Besilate or Norvasc, is a commonly used cardiovascular medication primarily indicated for the treatment of hypertension (high blood pressure) and angina pectoris (chest pain due to reduced blood flow to the heart).
Basic Information
English Name: Amlodipine Besylate
Chinese Name: 苯磺酸氨氯地平
Other Names: Norvasc, Amlodipine Besilate, etc.
CAS Number: 111470-99-6
Molecular Formula: C26H31ClN2O8S
Molecular Weight: 567.05
Drug Characteristics
Drug Type: Amlodipine Besylate is a long-acting calcium channel blocker belonging to the dihydropyridine class of drugs.
Mechanism of Action: It works by inhibiting the entry of calcium ions into vascular smooth muscle cells, thereby dilating blood vessels and reducing peripheral vascular resistance, which leads to a reduction in blood pressure. Additionally, it increases coronary blood flow, improving myocardial perfusion and relieving angina symptoms.
Clinical Applications
Hypertension: Amlodipine Besylate can be used alone or in combination with other antihypertensive agents to control blood pressure.
Angina Pectoris: Including chronic stable angina and vasospastic angina, Amlodipine Besylate can also be administered alone or in conjunction with other antianginal drugs to alleviate symptoms.
Drug Interactions
Amlodipine Besylate interacts with multiple medications, including:
When combined with beta-blockers, it can effectively treat angina or hypertension but may lead to severe hypotension or bradycardia.
Co-administration with amiodarone may further suppress sinus rhythm or exacerbate atrioventricular block.
Concurrent use with nonsteroidal anti-inflammatory drugs or oral anticoagulants may increase the risk of gastrointestinal bleeding.
In summary, Amlodipine Besylate is a vital cardiovascular medication with blood pressure-lowering and angina-relieving effects.
