Choline Fenofibrate, also known as Fenofibrate Choline Salt or ABT-335, is the choline salt form of Fenofibric acid. It belongs to a class of drugs known as fibrates, which are used primarily to treat hyperlipidemia, specifically high levels of triglycerides and low-density lipoprotein (LDL) cholesterol, while also raising high-density lipoprotein (HDL) cholesterol levels.
Key Points:
Chemical Name: Choline Fenofibrate
Synonyms: Fenofibrate Choline Salt, ABT-335
CAS Number: 856676-23-8
Molecular Formula (varies depending on representation, but typically includes C22H28ClNO5 or a combination reflecting the choline and fenofibric acid components)
Molecular Weight: Approximately 421.91 (exact value may vary slightly)
Pharmacological Action:
Upon administration, Choline Fenofibrate is hydrolyzed in the gut to release free Fenofibric acid, which is a peroxisome proliferator-activated receptor (PPAR) alpha agonist. This mechanism of action leads to a reduction in triglycerides and LDL cholesterol levels, as well as an increase in HDL cholesterol levels, thereby improving dyslipidemia.
Clinical Applications:
Indications: Used to treat hyperlipidemia, particularly when dietary modifications alone are insufficient. It is particularly effective in lowering triglyceride levels and treating mixed dyslipidemia.
Storage Conditions:
Store Choline Fenofibrate at room temperature or as specified by the manufacturer's instructions.
Protect from excessive heat, moisture, and direct sunlight.
