Tadalafil is a medication used to treat male erectile dysfunction (ED) and belongs to the PDE5 inhibitor class.
I. Basic Information
English Name: Tadalafil
CAS Number: 171596-29-5
Molecular Formula: C22H19N3O4
Molecular Weight: 389.41
II. Pharmacological Action
Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). PDE5 is an enzyme that degrades cGMP, a crucial second messenger in cellular functions.
During sexual stimulation, local nitric oxide release is inhibited by Tadalafil, resulting in increased cGMP levels within the corpus cavernosum of the penis. This leads to smooth muscle relaxation, blood flow into the penile tissues, and subsequent erection.
III. Drug Characteristics
Tadalafil exhibits high selectivity, rapid onset, and a long half-life.
It promotes vasodilation, enhancing blood flow to the male reproductive organs and the lungs, thereby aiding in the restoration of normal erectile function and alleviating pulmonary arterial hypertension.
