Fluticasone Propionate, also known as Fluticasone Propionate Monohydrate, is a widely used medication primarily for treating nasal-related conditions.
I. Basic Information
English Name: Fluticasone Propionate
Alternative Names: Fluticasone Propionate Monohydrate
Chemical Formula: C25H31F3O5S
Molecular Weight: 500.571
CAS Registry Number: 80474-14-2
II. Pharmacological Action
Fluticasone Propionate is a corticosteroid medication with potent anti-inflammatory and anti-allergic effects. Its primary mechanisms of action include:
Anti-inflammatory Effect: By inhibiting phospholipase A, it affects the synthesis of inflammatory mediators such as prostaglandins and leukotrienes, thereby reducing inflammatory reactions. In nasal diseases, inflammation is the primary cause of nasal mucosa swelling, congestion, and increased secretions. Fluticasone Propionate can effectively alleviate these symptoms by inhibiting inflammation.
Immunomodulatory Effect: It suppresses excessive immune reactions, reduces the activity of immune cells, and decreases the sensitivity of nasal tissues to allergens, helping to reduce the occurrence of allergic reactions and lower disease recurrence rates.
Inhibition of Tissue Proliferation: In conditions such as sinusitis and nasal polyps, excessive tissue proliferation can cause nasal obstruction and mucus retention. Fluticasone Propionate inhibits excessive tissue proliferation, reducing nasal stenosis and obstruction, and improving breathing.
III. Indications
Fluticasone Propionate is primarily used for the treatment of the following conditions:
Prophylactic Treatment of Asthma: Through its anti-inflammatory and immunomodulatory effects, it reduces asthma symptoms and controls disease progression.
Allergic Rhinitis: Including the prevention and treatment of seasonal and perennial allergic rhinitis. Fluticasone Propionate nasal spray can alleviate nasal symptoms such as itching, sneezing, and rhinorrhea.
Dermatological Conditions (as per international data): For skin conditions sensitive to glucocorticoids, such as psoriasis, atopic dermatitis, and eczema.
