Sitagliptin Phosphate

Sitagliptin Phosphate is a competitive, β-amino acid-derived dipeptidyl peptidase-4 (DPP-4) inhibitor with hypoglycemic activity. 

Basic Information

• English Name: Sitagliptin Phosphate

• CAS Number: 654671-78-0

• Molecular Formula: C16H18F6N5O5P

• Molecular Weight: 505.31

Pharmacological Action

Sitagliptin Phosphate inhibits DPP-4, thereby increasing the active forms of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which in turn increases insulin release and decreases glucagon levels in a glucose-dependent manner. This mechanism of action helps improve glycemic control in patients with type 2 diabetes.

Indications

• Indications: Januvia (Sitagliptin Phosphate Tablets) is used in combination with diet and exercise to improve glycemic control in patients with type 2 diabetes.