Ganirelix Acetate is a synthetic decapeptide compound that acts as a gonadotropin-releasing hormone (GnRH) antagonist.
Basic Information
English Name: Ganirelix Acetate
CAS Number: 123246-29-7
Molecular Formula: C80H113N18O13Cl
Molecular Weight: Approximately 1570.34
Pharmacological Action
Ganirelix Acetate acts as a GnRH antagonist, competitively blocking the GnRH receptors on the pituitary gonadotropic cells, thereby inhibiting the secretion of gonadotropins (luteinizing hormone, LH, and follicle-stimulating hormone, FSH). This inhibitory effect is more pronounced on LH than on FSH, helping to control ovarian stimulation cycles and prevent premature LH surges.
Clinical Applications
Ganirelix Acetate is primarily used in controlled ovarian stimulation protocols during assisted reproductive technologies (ART) such as in vitro fertilization (IVF) to prevent premature LH surges, thereby improving pregnancy success rates. The drug is associated with fewer adverse reactions, higher pregnancy rates, and shorter treatment cycles, providing significant advantages over similar medications.
