Salbutamol Sulfate is a commonly used bronchodilator.
I. Basic Information
CAS Number: 51022-70-9
English Name: Albuterol Sulfate
II. Pharmacological Actions
Salbutamol Sulfate is the first highly selective β2 receptor agonist with sufficient bronchodilating effects. It primarily works by selectively stimulating β2 receptors on bronchial smooth muscles, relaxing the muscles, and thus alleviating bronchial constriction. Additionally, Salbutamol Sulfate exhibits the following pharmacological effects:
Anti-inflammatory Effect: Inhibits congestion, edema, and other inflammatory manifestations in bronchial mucosa.
Anti-allergic Effect: Inhibits the release of allergic reaction mediators from mast cells and other sensitized cells, thereby reducing allergic reactions.
Anti-arrhythmic Effect: In conditions such as arrhythmias, it reduces myocardial oxygen consumption, alleviating chest tightness and shortness of breath.
Uterine Smooth Muscle Relaxation: Relaxes uterine smooth muscles, aiding in pregnancy, but note that it should be stopped 6 hours before delivery to prevent postpartum hemorrhage.
III. Clinical Applications
Salbutamol Sulfate is mainly used for the treatment of various types of airway obstructive diseases, such as:
Bronchial Asthma: For the acute relief and long-term treatment of bronchial asthma.
Asthmatic Bronchitis: Alleviates bronchoconstriction symptoms in patients with asthmatic bronchitis.
Emphysema: Reduces dyspnea symptoms in patients with emphysema.
Furthermore, Salbutamol Sulfate can also be used to prevent preterm labor, threatened abortion, and intrauterine growth retardation in high-risk pregnancies.
