Molecular Weight: 466.02 (alternatively stated as 465.97, minor variations due to hydrogen ion inclusion/exclusion in calculations)
Appearance: White crystalline powder
Chemical Properties
Melting Point: 145-148°C
Boiling Point: 585.9°C at 760 mmHg
Flash Point: 308.1°C
Vapor Pressure: 1.43E-14 mmHg at 25°C
Pharmacological Action
Sarpogrelate Hydrochloride is a selective 5-HT2R antagonist with pKi values of 8.52, 6.57, and 7.43 for 5-HT2A, 5-HT2B, and 5-HT2C receptors, respectively.
It lacks significant antagonistic activity against 5-HT1, 5-HT3, 5-HT4, α1-, α2-, and β-adrenoceptors, histamine H1, H2, and muscarinic M3 receptors.
It exhibits cardioprotective activity in vivo and is used as an antiplatelet compound.
Uses
Sarpogrelate Hydrochloride is primarily used to improve ischemic symptoms such as ulcers, pain, and cold sensations caused by chronic arterial occlusion.
It can also be used in the research of vascular diseases related to thrombosis.
Storage and Stability
Storage conditions may vary by supplier, but it is generally recommended to store at low temperatures, such as -20°C or lower, to ensure stability and activity.
In summary, Sarpogrelate Hydrochloride is a chemical substance with specific pharmacological actions and wide-ranging applications, particularly in the medical field.
