Olodaterol Hydrochloride

Olodaterol Hydrochloride is a selective long-acting β2-adrenergic receptor (β2-AR) agonist. 

I. Basic Information

• English Name: Olodaterol Hydrochloride

• CAS Number: 869477-96-3

• Molecular Formula: C21H27ClN2O5

• Molecular Weight: 422.90

II. Pharmacological Effects

• Receptor Selectivity: Olodaterol Hydrochloride has high selectivity for β2-AR (EC50=0.1 nM; pKi=9.14 for human β2-adrenoceptor) and shows significant selectivity compared to β1-AR and β3-AR subtypes.

• Biological Activity:

• It can increase intracellular cAMP levels in a concentration-dependent manner.

• In vitro studies have shown that it can interfere with FGF-induced signal cascade phosphorylation and attenuate growth factor-induced motility and proliferation.

• In vivo studies have demonstrated its antifibrotic efficacy, accelerating weight recovery to control levels and attenuating TGF-β-induced lung fibrosis.

III. Application Fields

• Scientific Research: Widely used in research fields such as endocrinology, inflammation/immunology, particularly in studies related to G protein-coupled receptor/G protein signaling pathways.

• Drug Development: Due to its properties as a selective long-acting β2-AR agonist, Olodaterol Hydrochloride has potential applications in the treatment of respiratory diseases such as chronic obstructive pulmonary disease (COPD) and lung fibrosis.