Ambroxol Hydrochloride is a widely used expectorant with various pharmacological effects and clinical applications.
I. Basic Information
English Name: Ambroxol Hydrochloride
CAS Number: 23828-92-4
Molecular Formula: C13H19Br2ClN2O
Molecular Weight: 414.56
Physical Properties: Melting point of 233-234.5°C
II. Pharmacological Effects
As an expectorant, Ambroxol Hydrochloride primarily acts on respiratory secretory cells and exhibits multiple pharmacological effects:
Regulation of Mucus Secretion: Ambroxol Hydrochloride increases the secretion of serous glands in the respiratory mucosa and reduces the secretion of mucous glands, thereby lowering the viscosity of sputum and making it thinner and easier to expel.
Promotion of Ciliary Movement: It also increases the frequency and intensity of ciliary movement in the respiratory tract, facilitating sputum expulsion and the self-cleaning function of the respiratory tract.
Promotion of Lung Surfactant Synthesis: Ambroxol Hydrochloride promotes the synthesis of lung surfactant, helping to maintain alveolar stability and improve lung function.
Enhancement of Antibiotic Efficacy: When used in combination with antibiotics (such as amoxicillin, cefuroxime, erythromycin, etc.), it can increase the concentration of antibiotics in lung tissue, enhancing their antibacterial efficacy.
Antioxidant Effect: Ambroxol Hydrochloride has a significant antioxidant effect, inhibiting the damaging effects of reactive free oxygen radicals and combating lung disease pathologies.
III. Clinical Applications
Ambroxol Hydrochloride is widely used in the clinical treatment of various respiratory diseases, including:
Acute and Chronic Respiratory Diseases: Such as acute and chronic bronchitis, bronchial asthma, bronchiectasis, tuberculosis, etc., causing thickened sputum and difficulty in expectoration.
Neonatal Respiratory Distress Syndrome: Ambroxol Hydrochloride promotes the biosynthesis and secretion of endogenous lung surfactant, helping to improve neonatal respiratory function.
Adjunctive Therapy for Lung Surgery: Used before and after surgery to prevent and treat lung complications.
