L-Alanyl-L-Glutamine

Also known as L-Alanine-L-Glutamine or DIPEPTIVEN, L-Alanyl-L-Glutamine is a glutamine dipeptide with various biological activities and applications. 

Basic Information

• English Name: L-Alanyl-L-Glutamine

• CAS Number: 39537-23-0

• Molecular Formula: C8H15N3O4

• Molecular Weight: 217.22

Physical and Chemical Properties

• Density: Approximately 1.5 ± 0.1 g/cm³ (may vary slightly from different sources)

• Boiling Point: 615°C

• Melting Point: 215°C

• Flash Point: >110°C

• Solubility: Easily soluble in water, almost insoluble or insoluble in methanol, slightly soluble in glacial acetic acid

Biological Activities and Uses

1. Parenteral Nutrition: L-Alanyl-L-Glutamine is used for parenteral nutrition, providing glutamine to patients receiving parenteral nutrition and supplementing amino acid solutions. It helps prevent increased intestinal permeability and atrophy caused by long-term use of parenteral nutrition.

2. Promotion of Positive Nitrogen Balance and Muscle Protein Synthesis: L-Alanyl-L-Glutamine promotes positive nitrogen balance and regulates muscle protein synthesis, helping to maintain the body's protein balance.

3. Immune Function Enhancement: It enhances immune function and prevents the occurrence of bacteremia, which is particularly important for patients who need to strengthen their immune systems.

4. Antioxidant and Anti-inflammatory Effects: L-Alanyl-L-Glutamine benefits the antioxidant system, reduces inflammation, and may regulate the heat shock protein (HSP) response in catabolic conditions.

5. Application in Cell Culture: In cell culture, L-Alanyl-L-Glutamine is often used as a substitute for L-glutamine because it is stable in aqueous solutions and does not spontaneously degrade into ammonia and pyrrolidine carboxylic acid like L-glutamine.