Synonyms: Carbonic acid, compd. with 2-(chloromethyl)oxirane polymer with 2-propen-1-amine (Sevelamer Carbonate); 2-Propen-1-amine polymer with (chloromethyl)oxirane carbonate, etc.
Physical and Chemical Properties
Molecular Formula: (C3H7N·C3H5ClO)x·xCH2O3
Molecular Weight: Approximately 211.64 g/mol (for monomeric units; polymeric forms will have higher molecular weights)
Appearance: White to off-white solid
Solubility: <4.74 mg/mL (solubility in DMSO may vary)
Stability: Stable under normal storage conditions (room temperature, inert atmosphere)
Pharmaceutical and Biological Properties
Phosphate Binder: Sevelamer Carbonate is a non-absorbed phosphate binder used to treat hyperphosphatemia in patients with chronic kidney disease (CKD) undergoing hemodialysis.
Mechanism of Action: It binds to phosphate in the gut, forming insoluble calcium phosphate complexes that are excreted in the feces, thereby reducing serum phosphate levels.
Additional Benefits: In addition to its phosphate-binding properties, Sevelamer Carbonate may also lower total cholesterol levels by binding to bile acids in the gut.
