Melting Point: Approximately 253 °C (may vary slightly depending on source)
Flash Point: 177.4±30.3 °C
Vapor Pressure: 0.0±1.6 mmHg at 25°C
Solubility: Insoluble in water, but soluble in methanol, chloroform, ethanol, dimethyl sulfoxide (DMSO), and propanol.
Chemical Properties
Stability: Stable under normal conditions at room temperature and pressure. Avoid contact with strong oxidizing agents.
LogP: 3.24 (a measure of hydrophobicity)
PSA (Polar Surface Area): 58.20000 Ų
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 2
Topological Polar Surface Area: 58.2 Ų
Heavy Atom Count: 27
Complexity: 678
Mechanism of Action
Finasteride is a potent and reversible inhibitor of the steroid 5α-reductase type II (SRD5A2) enzyme. By inhibiting this enzyme, Finasteride blocks the conversion of testosterone to dihydrotestosterone (DHT) in peripheral tissues. This reduction in DHT levels leads to a decrease in DHT concentration in the serum and tissues, which can reverse the miniaturization of hair follicles and promote hair growth in men with androgenic alopecia (male pattern baldness).
Uses
Finasteride is primarily used for the treatment of male pattern baldness (androgenic alopecia) and benign prostatic hyperplasia (BPH). It promotes hair growth and prevents further hair loss in men with male pattern baldness. In addition, it is also used to reduce the risk of acute urinary retention and the need for surgical intervention in men with BPH.
