Basic Information

• Product Name: Pomalidomide

• CAS Number: 19171-19-8

• Chemical Formula: C13H11N3O4

• Molecular Weight: 273.244 g/mol

Physical and Chemical Properties

• Appearance: White crystalline powder

• Density: 1.6±0.1 g/cm³

• Boiling Point: 582.9±45.0 °C at 760 mmHg

• Melting Point: 318.5 - 320.5 °C

• Flash Point: 306.3±28.7 °C

Biological Activity

• Pomalidomide is an antiangiogenic and immunomodulatory agent.

• It inhibits TNF-α release in LPS-stimulated human PBMCs with an IC50 of 13 nM.

• Pomalidomide also inhibits whole blood TNF-α with an IC50 of 25 nM.

• It has antitumor activity and enhances T-cell and natural killer (NK) cell-mediated immunity.

• Pomalidomide inhibits the production of proinflammatory cytokines by monocytes, such as TNF-α and IL-6.

Mechanism of Action

• Pomalidomide, a thalidomide analog, interacts with the E3 ligase cereblon and induces the degradation of the essential Ikaros transcription factors.

• It acts as a molecular glue and binds to specific targets to regulate cellular processes.

Applications

• Pomalidomide is used in the research and treatment of multiple myeloma, especially in patients who have received at least two prior therapies including lenalidomide and bortezomib and have not responded to treatment or have progressed within 60 days after the last treatment.

• It is also used in the research of other cancers and immune-related diseases.