Appearance: Light yellow to yellow crystalline powder
Melting Point: 195 °C
Boiling Point: 561.26 °C
Flash Point: 11 °C
Density: 1.41 g/cm³
Solubility: Easily soluble in dilute alkali, acid, or carbonate solutions of alkali metals; slightly soluble in dilute hydrochloric acid; almost insoluble in water, ethanol, chloroform, and ether.
Biological Activity
Methotrexate is an antimetabolite and antifolate agent that inhibits dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate and inhibiting DNA synthesis.
It also acts as an immunosuppressant and antineoplastic agent.
Applications
Methotrexate is used in the research and treatment of rheumatoid arthritis.
It is also used in the research and treatment of various cancers, such as acute lymphoblastic leukemia.
