Appearance: White or pale yellow crystalline powder
Melting Point: 96-97°C
Boiling Point: 329.1°C at 760 mmHg
Flash Point: 152.7°C
Density: 1.137 g/cm³ (or 1.1±0.1 g/cm³)
Refractive Index: 1.592
Solubility: Easily soluble in water
Storage Conditions: Store in a dry, room temperature environment under seal.
Pharmacological Effects
Antifibrotic Activity: Pirfenidone is a pyridinone compound with broad-spectrum antifibrotic activity, capable of preventing and reversing fibrosis and scar formation.
Inhibition of Collagen Synthesis: By reducing the expression of growth factors related to fibroblasts in organs such as the lungs and kidneys (e.g., bFGF, TGF-β, CTGF, and TIMP-1), pirfenidone inhibits collagen synthesis.
Anti-inflammatory Effects: It exerts anti-inflammatory effects mainly by inhibiting the expression of inflammatory mediators, reducing vascular permeability, and decreasing the accumulation of neutrophils and inflammatory cells.
Antioxidant Effects: Pirfenidone exhibits antioxidant activity by scavenging free radicals, inhibiting lipid peroxidation, and alleviating oxidative stress.
