Appearance: Pale yellow to yellow crystalline powder
Melting Point: Ranges from 176°C to 184°C (may vary slightly depending on source)
Density: Approximately 1.49 g/cm³ or 1.5±0.1 g/cm³ (minor variations may occur)
Refractive Index: Approximately 1.638 or 1.692 (minor variations may exist)
Solubility: Soluble in water
Chemical and Biochemical Properties
Chemical Name: N-[5-[N-Methyl-N-(2-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl)amino]-2-thiophenecarbonyl]-L-glutamic acid
Mechanism of Action: Raltitrexed is a folate-based thymidylate synthase (TS) inhibitor that undergoes rapid and extensive metabolism in vivo to form more active polyglutamated derivatives. It also inhibits dihydrofolate reductase (DHFR). As a potent antimetabolite antitumor agent, raltitrexed selectively inhibits thymidylate synthase, thereby inhibiting DNA and RNA synthesis, demonstrating antitumor activity in vivo.
