I. Basic Information

• Product Name: Olaparib

• CAS Number: 763113-22-0

• Chemical Formula: C24H23FN4O3

• Molecular Weight: 434.46 g/mol

II. Physical Properties

• Appearance: White powder

• Density: Approximately 1.43 g/cm³ (also reported as 1.4±0.1 g/cm³)

• Melting Point: Not specifically provided

• Boiling Point: Not specifically provided

• Refractive Index: 1.702

• Solubility: Not detailed regarding specific solvents, but typically formulated into oral dosage forms such as capsules.

III. Chemical Properties and Mechanism of Action

• Category: Poly(ADP-ribose) polymerase (PARP) inhibitor

• Mechanism of Action: Olaparib inhibits the activity of PARP-1 and PARP-2, blocking the DNA repair pathway in cancer cells. When cancer cells have mutations in BRCA1 or BRCA2 genes, which impair DNA damage repair function, the role of PARP becomes particularly important. By blocking this repair pathway, Olaparib enables cancer cells to be unable to effectively repair DNA damage, ultimately leading to cancer cell death.

IV. Indications and Uses

• Olaparib has been approved for the treatment of various malignancies, including but not limited to:

• Advanced ovarian cancer, especially in patients with BRCA mutations.

• Epithelial ovarian cancer, fallopian tube cancer, or primary peritoneal cancer.

• HER2-negative metastatic breast cancer, particularly in patients with BRCA mutations.

• Pancreatic cancer in patients with pathogenic or likely pathogenic germline BRCA mutations.