Boiling Point: 133-134°C (Note: This boiling point may refer to a specific solvent system or condition; the pure compound itself may have a different boiling point.)
Flash Point: 64°F (18°C; Note: Flash point values can vary depending on the method used for determination.)
Solubility: Soluble in water at 10 mg/mL (clear)
Storage Conditions: 2-8°C (or store at room temperature protected from light, but specific conditions may vary by supplier)
III. Chemical Properties and Biological Activity
Chemical Properties: Imatinib Mesylate is the mesylate salt of imatinib, with a stable chemical structure.
Biological Activity:
Multi-target Inhibition: Imatinib Mesylate is a multi-target receptor tyrosine kinase inhibitor that selectively inhibits the kinase activity of BCR/ABL, v-Abl, PDGFR, c-kit, etc.
Antitumor Effects: Imatinib Mesylate inhibits Bcr-Abl tyrosine kinase at the cellular level both in vitro and in vivo, inhibiting the proliferation and inducing apoptosis of Bcr-Abl-positive cell lines and fresh cells from Ph-chromosome-positive chronic myeloid leukemia (CML) and acute lymphocytic leukemia (ALL) patients. Additionally, it inhibits the tyrosine kinases of platelet-derived growth factor (PDGF) receptor, stem cell factor (SCF), and c-Kit receptor, thereby inhibiting cellular behaviors mediated by PDGF and SCF.
In Vitro Studies: In vitro studies have shown that Imatinib Mesylate inhibits various tumor cell lines, such as human bronchial carcinoid cell line NCI-H727 and human pancreatic carcinoid cell line BON-1.
In Vivo Studies: In vivo studies have demonstrated that Imatinib Mesylate inhibits tumor growth in mice and exhibits inhibitory effects on carotid artery lipid accumulation in high-fat-fed ApoE(-/-) mice.
