I. Basic Information

• Product Name: Axitinib

• CAS Number: 319460-85-0

• Molecular Formula: C22H18N4OS

• Molecular Weight: 386.47

II. Physical Properties

• Appearance: White to off-white crystalline solid, typically in powder form.

• Melting Point: 213-215°C (some sources indicate 218.4°C)

• Boiling Point: 668.9±55.0°C (Predicted)

• Density: 1.4 (units unspecified)

• Solubility: Highly soluble in DMSO, ≥8 mg/mL.

• Storage Conditions: Store at -20°C, protected from light and sealed.

III. Chemical Properties

• Axitinib is a tyrosine kinase inhibitor (TKI) with high specificity.

• It disrupts tumor angiogenesis by inhibiting the activity of vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, and VEGFR-3), thereby inhibiting cancer progression.

IV. Pharmacological Action

• Axitinib is primarily used to treat advanced or metastatic renal cell carcinoma (RCC).

• By inhibiting multiple VEGFRs and other related kinases, it prevents the formation of tumor blood vessels, inhibiting tumor growth and metastasis.

• Axitinib is also used to treat RCC patients who do not respond well to other therapies, such as immune checkpoint inhibitors or other TKIs.