I. Basic Information

• Product Name: Chlorambucil

• CAS Number: 305-03-3

• Molecular Formula: C14H19Cl2NO2

• Molecular Weight: 304.21

II. Physical Properties

• Appearance: White to off-white crystalline powder

• Melting Point: 65-69°C

• Solubility: Extremely soluble in acetone, freely soluble in ethanol or DMSO (>50 mg/mL), insoluble in water

• Density: 1.25 g/cm³ (Predicted)

III. Chemical Properties

• Chlorambucil is a nitrogen mustard derivative and acts as a bifunctional alkylating agent. It forms unstable ethylene imines, exerting its cytotoxic effects by interfering with DNA and RNA functions.

IV. Pharmacological Action

• Chlorambucil is less toxic than any other nitrogen mustard drug at conventional doses.

• It is sensitive to proliferating cells, especially those in the G1 and M phases, and is considered a non-cell-cycle-specific drug.

• It has a selective inhibitory effect on lymphocytes.