Solubility: Easily soluble in organic solvents such as ethanol and ethyl acetate, practically insoluble in water
UV Maximum Absorption: 230nm, 275nm, 283nm
III. Chemical Properties
Category: A semisynthetic analog of paclitaxel, belonging to microtubule depolymerization inhibitors
Mechanism of Action: Acts on the microtubule or tubulin system, promoting the assembly of microtubule dimers into microtubules and preventing the depolymerization process, thereby stabilizing microtubules. It is a cell cycle-specific drug that arrests cells in the G2 and M phases, inhibiting the mitosis and proliferation of cancer cells
IV. Pharmaceutical Characteristics
Antitumor Activity: Demonstrates significant antitumor effects and is clinically used primarily for the treatment of metastatic breast cancer and non-small cell lung cancer
Drug Metabolism: Exhibits biphasic distribution with a plasma clearance rate of 2.2 L/Kg.h. The highest radioactive activity is found in the liver, gallbladder, small intestine, and stomach contents
