Appearance and Character: The active pharmaceutical ingredient appears as a white or light brown/pale pink powder, with some sources describing it as a grayish-white to pale pink crystalline solid.
Melting Point: 212°C (decomposition)
Boiling Point: 526.6ºC at 760 mmHg
Flash Point: 272.3ºC
Density: 1.97 g/cm³ (or 2.0±0.1 g/cm³, with slight variations in data from different sources)
Solubility: Slightly soluble in dimethyl sulfoxide (DMSO), sparingly soluble in water, very slightly soluble in methanol, practically insoluble in ethanol, and sparingly soluble in glacial acetic acid. Alternatively, it is soluble in DMF (2 mg/mL), DMSO (3 mg/mL), and as a colloidal suspension in PBS (pH 7.2).
Chemical Properties
Category: An orally active DNA alkylating agent and also an autophagy and apoptosis promoter.
Mechanism of Action: It spontaneously and rapidly degrades in vivo to produce the active metabolite MTIC, thereby exerting antitumor effects. It is effective against tumor cells characterized by low levels of O6-alkylguanine-DNA alkyltransferase (OGAT) and functional mismatch repair systems.
Pharmaceutical Properties
Indications: Suitable for the treatment of malignant gliomas and metastatic melanomas.
Dosage and Administration: Determined based on the specific condition of the patient and medical guidance.
Precautions:
Storage Conditions: Typically stored at 2~8ºC, protected from light, and some products require storage under nitrogen.
Temozolomide as a monotherapy may not significantly increase median survival time (MST), but in combination with other drugs (such as NU1025), it may prolong patient survival.
