Appearance: Cefodizime Sodium is a white to slightly yellow powder or crystalline powder, odorless or with a slight specific odor.
Solubility: It is highly soluble in water but almost insoluble in anhydrous ethanol or ether.
Melting Point: 196~207°C
III. Chemical Properties
Stability: It has a certain degree of hygroscopicity and should be stored at 2~8°C.
Reactive Characteristics: Cefodizime Sodium is a third-generation cephalosporin for parenteral use. It has a high affinity for proteins involved in cell wall synthesis in sensitive bacteria. It is insensitive to most β-lactamases and has antibacterial activity against both Gram-positive and Gram-negative bacteria. It is stable to β-lactamases, cephalosporinases, and penicillinases.
IV. Pharmaceutical Properties
Antibacterial Spectrum: Cefodizime Sodium has a broad antibacterial spectrum, including most clinically relevant Gram-positive, Gram-negative, aerobic, and anaerobic bacteria.
Immunoenhancing Effects: Cefodizime Sodium, invented by Hoechst AG, is the first third-generation cephalosporin with immunoenhancing properties. It enhances macrophage function, natural killer cell function, and B lymphocyte responsiveness. It also induces the production of interleukins and interferons, thereby enhancing the immune function of the human body.
Pharmacokinetics: After entering the body, Cefodizime Sodium is rapidly distributed into body fluids and tissues, with increased local concentrations exceeding the effective concentrations required to inhibit most pathogens. Most of it is excreted in non-metabolized form via the kidneys, with a serum half-life of 2.5 hours in individuals with normal renal function.
