Chemical Name: Tobramycin, also known as Tobromycin, with the chemical formula C18H37N5O9.
Molecular Weight: 467.514
CAS Number: 32986-56-4
EINECS Number: 251-322-5
II. Physical Properties
Appearance: Tobramycin is a white solid.
Density: 1.52 g/cm³
Melting Point: 178°C
Boiling Point: 775.4°C
Flash Point: 422.8°C
Solubility: Easily soluble in water, very slightly soluble in alcohol, and insoluble in chloroform and ether.
III. Chemical Properties and Antibacterial Mechanism
Chemical Properties: Tobramycin is an aminoglycoside antibiotic with broad-spectrum antibacterial activity.
Antibacterial Mechanism: Tobramycin binds to the ribosomal A-site, inhibiting protein synthesis and leading to bacterial death.
IV. Antibacterial Spectrum and Clinical Applications
Antibacterial Spectrum: Tobramycin is primarily effective against Gram-negative bacteria, such as Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter species, Proteus species, and Citrobacter species.
Clinical Applications:
Often used to treat severe infections caused by susceptible bacteria, including neonatal sepsis, septicemia, central nervous system infections (including meningitis), urinary tract and genital system infections, lung infections, biliary tract infections, abdominal infections, skin and soft tissue infections, etc.
Tobramycin can also be used for ocular bacterial infections, such as conjunctivitis and keratitis, especially for Gram-negative bacilli infections resistant to gentamicin.
