Chemical Information

• English Name: Otilonium Bromide

• Molecular Formula: C29H43BrN2O4

• Molecular Weight: 563.57 g/mol

• CAS Number: 26095-59-0

Pharmacological Actions

1.     Antispasmodic Activity:

o    Otilonium Bromide is primarily used for its antispasmodic effects. It helps to relax the smooth muscles in the gastrointestinal tract, which can help to alleviate symptoms such as cramps and abdominal pain commonly associated with conditions like Irritable Bowel Syndrome (IBS).

2.     Calcium Channel Blockade:

o    This compound acts as a calcium channel blocker in the smooth muscles of the gastrointestinal tract. By inhibiting calcium influx, it helps to reduce muscle contractions and spasms.

3.     Muscarinic Receptor Antagonism:

o    Otilonium Bromide also exhibits anticholinergic properties, meaning it can inhibit the action of the neurotransmitter acetylcholine on muscarinic receptors in the gut. This further contributes to its ability to reduce muscle spasms and motility.

4.     Local Effects:

o    The drug primarily acts locally in the gut with minimal systemic absorption, thus reducing the risk of systemic side effects.

5.     Relief from Gastrointestinal Disorders:

o    By reducing motility and relaxing the gut muscles, Otilonium Bromide helps in providing relief from symptoms associated with functional gastrointestinal disorders, such as bloating, discomfort, and abdominal pain.

6.     Minimal Central Nervous System Side Effects:

o    Due to its poor systemic absorption, Otilonium Bromide has fewer central nervous system (CNS) side effects compared to other antispasmodics that are systemically absorbed.