English Name: Mesalazine Chemical Name: 5-Aminosalicylic acid Molecular Formula: C7H7NO3 Molecular Weight: 153.14 g/mol CAS Number: 89-57-6
Pharmacological Actions
1.Anti-inflammatory Effect: Mesalazine is primarily used for its anti-inflammatory properties. It works by inhibiting the production of inflammatory mediators in the gastrointestinal tract. This includes the suppression of prostaglandin and leukotriene synthesis, as well as free radical scavenging.
2.Treatment of Inflammatory Bowel Disease (IBD): Mesalazine is commonly used to treat inflammatory bowel diseases such as Ulcerative Colitis and Crohn’s Disease. It helps reduce the inflammation and maintain remission.
3.Intestinal Mucosal Healing: Mesalazine promotes healing of the intestinal mucosa and can help in reducing the symptoms like diarrhea, rectal bleeding, and abdominal pain associated with IBD.
4.Modulation of Immune Response: It helps modulate the immune response in the gastrointestinal tract, reducing the autoimmune attack on the intestinal lining and mitigating symptoms of chronic intestinal inflammation.
5.Topical Anti-inflammatory Action: When administered orally, it has a topical effect on the intestinal mucosa, meaning it exerts its anti-inflammatory effect directly at the site of inflammation in the gut.
6.Reduces Oxidative Stress: Mesalazine also combats oxidative stress within the intestine by neutralizing free radicals which can cause further tissue damage.
