English Name: Upadacitinib (also known as ABT-494)
Chemical Name: (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide anhydrous
Molecular Formula: C17H19F3N6O
Molecular Weight: 380.368 (Note: slightly varying values such as 380.38 may be found in different sources)
Physical Properties
Density: Approximately 1.6±0.1 g/cm³
Refractive Index: 1.678
Melting Point: Not specifically provided
Boiling Point: Not specifically provided
Uses and Properties
Uses: Upadacitinib is primarily used as a cell culture research agent and as a potent and selective JAK1 inhibitor for the treatment of autoimmune diseases.
IC50 Value: 43 nM, demonstrating its high efficacy as a JAK1 inhibitor.
Storage and Safety
Storage Conditions: Room temperature, dry
Safety Information: Hazard code Xn (Europe) indicates harmful to the environment, requiring safe handling practices.
Other Information
English Aliases: ABT494; ABT 494; (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide, among others.
