Basic Information:
- Chemical Name: Agomelatine
- Other Names: Valdoxan, Thymanax, Melitor
- CAS Number: 138112-76-2
- Molecular Formula: C15H17NO2
- Molecular Weight: 243.30 g/mol

Pharmacological Action:
Agomelatine is an antidepressant with a unique mode of action. It is a melatonin receptor agonist and a selective serotonin receptor antagonist. Here are some of its primary pharmacological actions:

1.     Melatonin Receptor Agonist: Agomelatine acts as an agonist at MT1 and MT2 receptors, which helps regulate circadian rhythms and improve sleep patterns.

2.     Serotonin (5-HT2C) Antagonist: It antagonizes 5-HT2C receptors, which helps increase the release of norepinephrine and dopamine, particularly in the frontal cortex. This effect contributes to its antidepressant and anxiolytic properties.

3.     Mood Regulation: Through its dual action on melatonin and serotonin receptors, Agomelatine helps alleviate depressive symptoms and enhances mood and cognitive function.

4.     Sleep-Wake Cycle Enhancement: Its action as a melatonin receptor agonist helps to re-synchronize the sleep-wake cycle, thus improving sleep quality and duration.

5.     Minimal Sexual Side Effects: Unlike some other antidepressants, Agomelatine is noted for having minimal sexual side effects, making it a preferred option for individuals sensitive to this issue.