Sulpiride is an atypical antipsychotic and antidepressant in the benzamide class used primarily for the treatment of schizophrenia and major depressive disorder. Its pharmacological actions include:
1.Dopamine D2 Receptor Antagonism: Sulpiride primarily acts as a selective antagonist of dopamine D2 and D3 receptors, which helps in reducing psychotic symptoms associated with schizophrenia.
2.Antidepressant Properties: It has dose-dependent effects, where lower doses can have an antidepressant effect due to increased dopamine activity in certain brain regions.
3.Antiemetic Effect: By blocking dopamine receptors in the brain's chemoreceptor trigger zone (CTZ), Sulpiride can alleviate nausea and vomiting.
4.Prokinetic Activity: It enhances gastrointestinal motility by antagonizing dopamine receptors in the gastrointestinal tract.
