Basic Information

• Chemical Name: Tiapride Hydrochloride

• CAS Number: 51012-33-0

• Molecular Formula: C15H25ClN2O4S

• Molecular Weight: 364.88 g/mol

Pharmacological Effects

Tiapride is classified as an atypical antipsychotic and is primarily used to treat various neurological and psychiatric disorders. Its main pharmacological effects include:

1.     Dopamine D2 Antagonism:

o    Tiapride is known to have a high affinity for dopamine D2 receptors. It acts as an antagonist, reducing activity at these receptors.

o    This mechanism is particularly beneficial for managing symptoms associated with psychomotor agitation and aggressive behavior.

2.     Antipsychotic Effects:

o    Tiapride is utilized for its antipsychotic properties, especially in treating conditions like schizophrenia, Huntington's disease, and certain behavioral disorders in the elderly.

o    It helps alleviate symptoms such as hallucinations, delusions, and thought disturbances.

3.     Sedative and Anxiolytic Properties:

o    Tiapride exhibits sedative and anxiolytic effects, helping to calm agitated patients.

o    It is used to reduce anxiety and promote relaxation without causing significant drowsiness.

4.     Motor Function Improvement:

o    Patients with conditions like Tourette syndrome or motor tics benefit from Tiapride, as it helps reduce involuntary movements and tics.

o    It is also beneficial in treating dyskinesia, particularly in patients with Parkinson's disease.

5.     Alcohol Dependence Treatment:

o    Tiapride has been utilized to manage alcohol dependence, reducing cravings and withdrawal symptoms.

6.     Gastrointestinal Effects:

o    By modulating dopamine receptors in the gastrointestinal tract, Tiapride may improve gastrointestinal symptoms such as nausea and vomiting.