English Name: Doxazosin Mesylate; also known as 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine methanesulfonate, etc.
CAS Number: 77883-43-3
Molecular Formula: C24H29N5O8S
Molecular Weight: 547.58
II. Physical and Chemical Properties
Melting Point: 275-277°C.
Solubility: Slightly soluble in water, soluble in 15 volumes of water and 35 volumes of tetrahydrofuran, slightly soluble in methanol, and practically insoluble in acetone. It exhibits polymorphism (5.9), and some forms may be hygroscopic.
Storage Conditions: Recommended to be stored at 2-8°C and protected from light.
III. Application
Pharmaceutical Field: Doxazosin Mesylate is an active pharmaceutical ingredient used primarily in the treatment of hypertension. As a new generation of quinazoline-based α1-blocker, it reduces blood pressure by blocking α1 receptors, thereby expanding blood vessels and decreasing vascular resistance. Additionally, it selectively blocks α1-adrenergic receptors in prostatic smooth muscle stroma, capsule, and bladder neck, improving symptoms of benign prostatic hyperplasia (BPH).
IV. Pharmacological Effects
Doxazosin Mesylate is a highly selective α1-blocker that significantly lowers blood pressure and favorably modifies lipid metabolism, significantly reducing serum triglycerides and total cholesterol.
It also effectively slows the progression of benign prostatic hyperplasia, particularly alleviating urination difficulties caused by simple BPH.
VI. Safety Data
Hazard Symbols: GHS08, GHS09 (as per the Globally Harmonized System of Classification and Labelling of Chemicals)
Signal Words: Warning
Hazard Statements: H411-H373 (specific descriptions may involve health hazards and environmental hazards)
Precautionary Statements: Including but not limited to P260-P314-P501 (providing emergency response measures)
