Basic Information

• Chinese Name: 尼替西农

• English Name: Nitisinone

• Synonyms: 2-(2-Nitro-4-(trifluoromethyl)benzoyl)cyclohexane-1,3-dione; N-(5-nitro-2-(trifluoromethyl)phenyl)succinimide

• CAS Number: 104206-65-7

• Molecular Formula: C14H10F3NO5

• Molecular Weight: 329.23

Physical and Chemical Properties

• Melting Point: 129-131°C

• Boiling Point: 486.2±45.0°C (predicted)

• Density: 1.484±0.06 g/cm³ (predicted)

• Solubility: Soluble at ≥5 mg/mL in dimethyl sulfoxide

• pKa: 3.13±0.50 (predicted)

Uses and Biological Activity

• Nitisinone is a 4-hydroxyphenylpyruvate dioxygenase inhibitor with specific biological activity.

• In the medical field, Nitisinone is primarily used in the treatment of certain inherited metabolic disorders, such as tyrosinemia.

Safety Information

• Hazard Symbols: GHS07, GHS06

• Signal Words: Danger

• Hazard Statements: H311, H302 (specific descriptions may include acute toxicity, harm to aquatic life, etc.)