Synonyms: Granisetron HCl, 1-Methyl-N-[endo-9-methyl-9-azabicyclo[3.3.1]non-3-yl]-1H-indazole-3-carboxamide hydrochloride, among others
Molecular Formula: C18H25ClN4O
Molecular Weight: 348.87
Physical and Chemical Properties
Density: 1.33 g/cm³
Boiling Point: 532ºC at 760 mmHg
Melting Point: 290-292°C
Flash Point: 275.6ºC
Vapor Pressure: 0 mmHg at 25°C
Refractive Index: 1.69
Solubility: Freely soluble in water, slightly soluble in alcohol
Uses
Granisetron Hydrochloride is a highly selective 5-HT3 receptor antagonist used primarily for the prevention and treatment of nausea and vomiting caused by radiotherapy, chemotherapy, and surgery. It inhibits nausea and vomiting by antagonizing the 5-HT3 receptors in the central chemoreceptor trigger zone and the peripheral vagal nerve endings.
Safety Information
Safety Statements:
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S37: Use suitable gloves.
Risk Phrases:
R22: Harmful if swallowed.
R36: Irritating to eyes.
R62: Possible risk of impaired fertility.
R36/37/38: Irritating to eyes, respiratory system, and skin.
