Molecular Formula: Varies slightly in different sources, e.g., C4H9NO2, C16H24GdN4O8.C7H17NO5.H, C23H42GdN5O13, due to representation or aggregation state.
Molecular Weight: When the formula is C23H42GdN5O13, the molecular weight is 753.86
Physical Properties
Density: Some sources list it as 1.12345 g/cm³, but specific physical properties may vary depending on batches or preparation methods.
Melting Point, Boiling Point, Refractive Index: These are not detailed in all sources and may require specific experimental conditions for measurement.
Uses and Applications
Primary Use: As an intravenous contrast agent for magnetic resonance imaging (MRI). Gadolinium's paramagnetic properties enhance MRI contrast, allowing clearer visualization of pathological tissues.
Indications: Used in brain and spinal imaging, as well as other whole-body pathological examinations, including angiography.
Pharmacological Effects and Safety
Pharmacological Effects: Gadolinium DOTA Meglumine itself is pharmacologically inert and is a highly stable compound. Its contrast-enhancing effect in MRI is attributed to gadolinium's paramagnetic properties.
Safety: In animal studies at doses far exceeding clinical use, seizures and temporary respiratory distress were observed. After prolonged high-dose injections, reversible cellular vacuolation in adjacent renal tubules was seen, with no other significant effects. No teratogenic or mutagenic effects were found.
