Chemical Information:
- English Name: Ziprasidone Hydrochloride
- CAS Number: 138982-67-9
- Molecular Formula: C21H21ClN4OS.ClH
- Molecular Weight: 467.4

Pharmacological Action:

Pharmacological Class:
Ziprasidone Hydrochloride is classified as an atypical antipsychotic medication.

Mechanism of Action:
Ziprasidone works by affecting the actions of certain chemicals in the brain, primarily by:

1.     Antagonism of Serotonin and Dopamine Receptors:

o    Ziprasidone has high affinity for serotonin (5-HT2A) and dopamine (D2) receptors. By blocking these receptors, it can help reduce the symptoms of schizophrenia and bipolar disorder, such as hallucinations, delusions, and mood swings.

2.     Antagonism of Other Receptors:

o    It also has affinity for serotonin (5-HT1D and 5-HT2C), alpha-1 adrenergic, and histamine H1 receptors which contribute to its therapeutic effects and side effect profile.

3.     Reuptake Inhibition:

o    Ziprasidone acts as a serotonin and norepinephrine reuptake inhibitor, which means it can increase the levels of these neurotransmitters in the brain, further aiding its antipsychotic and mood-stabilizing effects.